Pharmacokinetics of fenoprofen enantiomers following intravenous administration of the racemate in cats.

CASTRO, E.; SORACI, A.L.; TAPIA, O.; FOGEL, F.

Madrid

Congreso; 7th EAVPT; 1997

The chiral inversion process is a characteristic metabolic pathway for different aryl-2-propionic acids or profens. Important variations have been observed between these individual compounds as well as between  animal species.  The stereoconversion  of FPF and KTF has been documented in a variety of species. However, there are no stereoselective metabolic studies of these compounds in cats. The aim of the present study was to investigate the comparative stereoconversion of R-(-)-FPF and R-(-)-KTF in this species