Fosfomycin concentrations in epithelial lining fluid in weaning piglets

SORACI, A.L.; PÉREZ, D; MARTINEZ, G; AMANTO, F TAPIA, M.O.; PAGGI , M.B

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

WILEY-BLACKWELL PUBLISHING, INC

Año: 2012 p. 1 - 4

0140-7783

Respiratory diseases are one of the most important problems in modern intensive swine production. These diseases are a common cause of morbidity and mortality in weaning pigs. The concentrations of antibiotics in epithelial lining fluid (ELF) reflect the antimicrobial activity for extracellular pathogens involved in respiratory diseases (Schentag & Ballow, 1991; Kiem & Schentag, 2008). Fosfomycin is a hydrosoluble bactericidal broad-spectrum antibiotic used in Central and South America and various Asian countries. Although fosfomycin showed clinical efficacy in the treatment of pulmonary diseases, concen- trations in ELF have not still been established in any species. Assuming that the determination of fosfomycin concentration in ELF (biophase) represents the key parameter for establishing efficacy of antibiotics, the objective of this work was to characterize the potential penetration of fosfomycin in ELF and its relationship with serum concentrations in weaning piglets