INVESTIGADORES
SORACI Alejandro Luis
artículos
Título:
Pharmacokinetics and Bioavailability of Calcium Fosfomycin in Post Weaning Piglets after Oral Administration
Autor/es:
PÉREZ, DENISA S. ; MARTÍNEZ, GUADALUPE ; SORACI, ALEJANDRO L. ; TAPIA, MARÍA O.
Revista:
International Journal for Agro Veterinary and Medical Sciences
Editorial:
Periodical of Shahzad & Co LLC
Referencias:
Año: 2012 vol. 6 p. 425 - 435
ISSN:
1999-9666
Resumen:
Calcium fosfomycin pharmacokinetics and bioavailability were studied in post weaning piglets
after oral administration at 30 mg/kg of bodyweight (BW)). Fosfomycin plasma concentrations were
measured by high-performance liquid chromatography MS/MS. The T1/2 was of 1.80 ± 0.89 h. Cmax, Tmax
and bioavailability were 3.60 ± 0.96 μg/mL, 3.00 ± 0.00 h and 20.0 ± 1.85 %, respectively. The area
under the fosfomycin concentration:time curve in plasma AUC(0-∞) was 45.48 ± 9.20 μg h/mL. Different
authors have determined a minimum inhibitory concentration ranging from 0.25 - 0.5 μg/mL for
Streptococcus sp. and Escherichia coli, respectively. Considering these minimum inhibitory
concentrations of sensitive bacteria to fosfomycin, taking into account fosfomycin is a time-dependent
antimicrobial and according to the values of fosfomycin plasma concentration vs. time profiles observed
in this study, it was determined that effective plasma concentrations of fosfomycin for sensitive bacteria
can be obtained following oral administration of fosfomycin at a dose of 30 mg/kg in piglets.