Protective effects of Yerba mate (IIex paraguariensis) on prostate cancer development

SANTIANO, FLAVIA E.; FERNÁNDEZ, MARÍA DE LOS ÁNGELES; ESPINO, MAGDALENA; ZYLA, LEILA E.; REY, LARA; GÓMEZ, SILVINA E.; BRUNA, FLAVIA A.; PISTONE-CREYDT, VIRGINIA; PIETROBON, ELISA; PÉREZ ELIZALDE, RAFAEL; SILVA, MARÍA F.; CARÓN, RUBÉN W.; LÓPEZ FONTANA, CONSTANZA M.

NUTRITION

ELSEVIER SCIENCE INC

Año: 2023 vol. 108

0899-9007

Objectives: Prostate cancer (PCa) is the most common adenocarcinoma in men >50 y of age. It has a long latency period, which provides time for preventive strategies like incorporating healthy eating habits. Yerba mate (YM) intake has been associated with numerous health benefits. Since YM is one of the most popular infusions in Argentina, the of this study was to examine the influence of YM on PCa development. Methods: We carried out an in vivo model of PCa through subcutaneous inoculation of transgenic adenocarcinoma of the mouse prostate-C1 cells in C57BL/6 mice. Subsequently, the animals were divided into two groups: mate (25 mg/mL of YM in drinking water, n = 15), and control (only drinking water, n = 15). We also developed an in vitro model to study the direct effects of YM on three human PCa cell lines: lymph node carcinoma of the prostate (LNCaP), PC-3, and DU-145. Results: Our in vivo model showed that YM intake slightly reduced body weight, increased the latency of tumor appearance (P