Streptomyces genus as a source of probiotics and its potential for its use in health

CUOZZO S. A.; ALEJANDRA DE MORENO DE LEBLANC; J.G. LEBLANC; N. HOFFMANN; GONZALO R. TORTELLA

MICROBIOLOGICAL RESEARCH

ELSEVIER GMBH

Año: 2023 vol. 266

0944-5013

The effect of a probiotic on gut microbiota depends not only on the species of microorganism but specifically on the strain. In human beings, as in other animals, specific probiotics have been associated with numerous beneficial properties, which include weight modulation (gain or loss), immune modulation, and prevention of many disorders such as lactose intolerance, cardiovascular diseases, and antibiotic-associated diarrhoea. Streptomyces are an essential group of soil bacteria in the Actinomycetes family. They are related to producing a wide range of secondary metabolites known for their beneficial effects on human health. However, according to the human microbiomeanalysis, a lower prevalence of Streptomyces genus exists than in other non-human microbiomes. This difference can be associated with current lifestyles. In this article, we review the benefits associated with different compounds produced by Streptomyces, with a particular focus on the production of exopolysaccharides, antibiotics, and other secondary metabolites and the potential innovative use of Streptomyces spp. as probiotics.