A GREEN METHOD FOR BETA-AMINOCROTONATES SYNTHESIS.

LAURA M. SANCHEZ; A. G. SATHICQ; G. T. BARONETTI; H. J. THOMAS; G. P. ROMANELLI

Foz do Iguazú

Conferencia; 4th International IUPAC Conference on Green Chemistry ? 4th ICGC; 2012

beta-aminocrotonates are versatile intermediates for the synthesis of many heterocycles. Also, beta-aminocrotonates have been previously evaluated as compounds with potent oral anticonvulsant activity at the voltage-dependent Sodium channel binding site in a manner similar to class 1 anticonvulsants Phenytoin, Carbamazepine, and Lamotrigine1. Continuing with our studies about Green Methodologies, we now present our findings about the catalytic preparation of crotonates using Wells-Dawson heteropolyacids under solvent-free conditions.