Spray drying of Rhamnus purshiana extract for direct compression and evaluation of laxative effect.

GALLO LOREANA; BUCCIARELLI ALEJANDRO; BIANCHI MELISA; SKLIAR MARIO; ALLEMANDI DANIEL

Rosario

Congreso; 41ª Reunión Anual de SAFE; 2009

Sociedad Argentina de Farmacología Experimental (SAFE)

During the last years, a notable increment in the use of the phytomedicines has been observed. Dry plant extracts (DPE) are generally used as active ingredients for the formulation of phytomedicines in the form of tablets. Rhamnus purshiana (Rhamnacea) is one of the most used plants due to its effective, economic and natural laxative action. The optimization of a spray drying process for the production of DPEs of R. purshiana is proposed in order to obtain DPEs with appopiated quality for direct compression (DC). A 2 ^ (5-1) fractional factorial stastical design was selected to study the effect of the processing variables on the DPEs quality. Physical and mechanical properties, hygroscopicity and process yielding of DPEs were studied. The fluid plant extract and colloidal silicon dioxide were the ingredients to be spray dried. Spray drying was performed in a laboratory scale Mini Spray Dryer. Operative conditions affected the spray dried powdres properties. DPEs with good flowability were obtained and a selected sample with these characteristics was used for laxative effect evaluation on CF-1 albino mice. A DPE with good flow properties for DC and significant laxative effect on mice was observed.