Valeriana officinales dry plant extract for direct compression: Preparation and characterization

GALLO LOREANA; RAMIREZ RIGO M.VERÓNICA; PIÑA JULIANA; PALMA SANTIAGO; ALLEMANDI DANIEL; BUCALÁ VERÓNICA

Scientia Pharmaceutica

Austrian Pharmacists' Publishing House

Año: 2012 vol. 80 p. 1013 - 1026

0036-8709

La revista Scientia Pharmaceutica se encuentra indexada en: Scopus (Elsevier), Academic Search Complete (EBSCO Publishing), Asian Science Citation Index (ASCI Database,CAB Abstracts (Centre for Agricultural Bioscience International), Chemical Abstracts (American Chemical Society), Chimica (Elsevier), Derwent Biotechnology Abstracts (Thomson Scientific, Derwent Drug File (Thomson Scientific), Directory of Open Access Journals (DOAJ,EMBASE/excerpta medica (Elsevier), Global Health (Centre for Agricultural Bioscience International), Google Scholar (Google), Hinari (World Health Organization), History of Science, Technology, and Medicine (Research Libraries Group), Index Copernicus (Index Copernicus Ltd.), International Pharmaceutical Abstracts (Thomson Scientific), Mass Spectrometry Bulletin (Royal Society of Chemistry), Master Journal List (Thomson Reuters) Medicinal and Aromatic Plants Abstracts (Scientific Publishers), Methods in Organic Synthesis (Royal Society of Chemistry), Natural Product Updates (Royal Society of Chemistry), Open J-Gate (Informatics Ltd), ProQuest Health & Medical Complete (Cambridge Information Group), ProQuest Pharma Collection (Cambridge Information Group), PSOAR (Pharmaceutical Sciences Open Access Resources) PubMed (United States National Library of Medicine), PubMed Central (United States National Library of Medicine), Socolar (China Educational Publications Import & Export Corporation), VINITI (All-Russian Institute of Scientific and Technical Information of the Russian Academy of Science), Zetoc (British Library).------------------------------------------------------------------------------------------------------------------------------- Abstract: Valeriana officinalis L. (Valerianaceae) is one of the most widely used plants for the treatment of anxiety and insomnia. Usually dry plant extracts, including V. officinalis, are hygroscopic materials with poor physico-mechanical properties that can be directly compressed. A V. officinalis dry extract with moderate hygroscocity is suitable for direct compression, and was obtained by using a simple and economical technique. The V. officinalis fluid extract was oven-dried with colloidal silicon dioxide as a drying adjuvant. The addition of colloidal silicon dioxide resulted in a dry plant extract with good physico-mechanical properties for direct compression and lower hygroscopicity than the dry extract without the carrier. The dry plant extract glass transition temperature was considerably above room temperature (about 72 °C). The colloidal silicon dioxide also produced an antiplasticizing effect, improving the powders physical stability. The pharmaceutical performance of the prepared V. officinalis dry extract was studied through the design of tablets. The manufactured tablets showed good compactability, friability, hardness, and disintegration time. Those containing a disintegrant (Avicel PH 101) exhibited the best pharmaceutical performance, having the lowest disintegration time of around 40 seconds.