Membranes Applied to Guided Bone Tissue Regeneration: Use of Hydroxyapatite Nanoparticles to Improve their Biological Properties

NOELIA D´ELIA; RAMON RIAL SILVA; JAVIER SARTUQUI; DANIEL ERCOLI; JUAN RUSO; PAULA MESSINA; GEMMA MESTRES

Encuentro; Nanomed-ar 2020; 2020

Fundación Balseiro-Fundación Argentina de Nanotecnología

Guided bone tissue regeneration is widely employed, especially in the oral maxillofacial region. The main objectives of the application of a barrier membrane are: (a) covering a bone defect supporting the ingrowth of osteogenic cells without competition from other cells, and (b) preventing micromovement of the bone graft . In recent years, various membranes applied for guided bone regeneration have been developed. Among them, biodegradable membranes have the advantage to avoid a second surgical procedure to extract them and bioactive membranes ensure tight bonding of the biomaterial within the host tissue. Our research group developed a biodegradable material composed of alginate crosslinked with hydroxyapatite nanoparticles. Alginate is widely used in biomedical applications due to its clinically proved biocompatibility, while hydroxyapatite nanoparticlesstimulate osteoblast differentiation and coagulation process.