Hydrophilic matrix system of a plant extract based on co-spray-dried powders: Extract release mechanisms study

GALLO, LOREANA; PIÑA, JULIANA; BUCALÁ, VERÓNICA; ALLEMANDI, DANIEL; RAMÍREZ RIGO, VERÓNICA

Rosario

Otro; RICiFa 2º Reunión Internacional de Ciencias Farmacéuticas; 2012

Universidad Nacional de Rosario

Hydrophilic matrices are one of the most widely used modified-release systems (MRS) for drug delivery. They consist of a compact containing a mixture of a drug and a hydrophilic polymer, which retard the drug release.1 There is yet a great potential for the development of novel herbal MRS. In particular, hydrophilic matrices based on medicinal plant extracts constitute a promising therapeutic strategy. Dried plant extracts offer numerous advantages over liquid forms. Nevertheless, these characteristics depend on the production steps. In this sense, spray-drying is a technique used to generate powders with precise quality specifications in continuous operation.2 The goal of this study was to develop a control-release spray dried co-processed powder based on a medicinal plant extract for matrices post-production, aiming to identify the mechanisms that modulate extract release.