INVESTIGADORES
DIAZ Maria Soledad
artículos
Título:
Parameter Estimation in Kinetic Models for Large Scale Metabolic Networks with Advanced Mathematical Programming Techniques
Autor/es:
JIMENA DI MAGGIO; JUAN C. DIAZ RICCI; MARIA SOLEDAD DIAZ
Revista:
COMPUTER AIDED CHEMICAL ENGINEERING
Editorial:
ELSEVIER
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 28 p. 355 - 360
ISSN:
1570-7946
Resumen:
In this work, we formulate a parameter estimation problem for a large-scale dynamic
metabolic network. The DAE system represents the dynamic model for the Embden-
Meyerhof-Parnas pathway, the phosphotransferase system and the pentose-phosphate
pathway of Escherichia coli K-12 W3110 (Chassagnole et al., 2002), with
modifications on several enzyme kinetics and the addition of fermentation reactions.
Model parameters have been estimated based on recently published experimental data
for this strain. Most sensitive parameters have been ranked by performing global
sensitivity analysis on the dynamic metabolic network (Di Maggio et al., 2009a,b).
Eleven kinetic parameters, including maximum reaction rates, inhibition and halfsaturation
constants, have been estimated with good agreement with available
experimental data.
modifications on several enzyme kinetics and the addition of fermentation reactions.
Model parameters have been estimated based on recently published experimental data
for this strain. Most sensitive parameters have been ranked by performing global
sensitivity analysis on the dynamic metabolic network (Di Maggio et al., 2009a,b).
Eleven kinetic parameters, including maximum reaction rates, inhibition and halfsaturation
constants, have been estimated with good agreement with available
experimental data.
modifications on several enzyme kinetics and the addition of fermentation reactions.
Model parameters have been estimated based on recently published experimental data
for this strain. Most sensitive parameters have been ranked by performing global
sensitivity analysis on the dynamic metabolic network (Di Maggio et al., 2009a,b).
Eleven kinetic parameters, including maximum reaction rates, inhibition and halfsaturation
constants, have been estimated with good agreement with available
experimental data.
modifications on several enzyme kinetics and the addition of fermentation reactions.
Model parameters have been estimated based on recently published experimental data
for this strain. Most sensitive parameters have been ranked by performing global
sensitivity analysis on the dynamic metabolic network (Di Maggio et al., 2009a,b).
Eleven kinetic parameters, including maximum reaction rates, inhibition and halfsaturation
constants, have been estimated with good agreement with available
experimental data.
Escherichia coli K-12 W3110 (Chassagnole et al., 2002), with
modifications on several enzyme kinetics and the addition of fermentation reactions.
Model parameters have been estimated based on recently published experimental data
for this strain. Most sensitive parameters have been ranked by performing global
sensitivity analysis on the dynamic metabolic network (Di Maggio et al., 2009a,b).
Eleven kinetic parameters, including maximum reaction rates, inhibition and halfsaturation
constants, have been estimated with good agreement with available
experimental data.