Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies.

SGUASSERO Y; CUESTA CB; ROBERTS KN; HICKS E; COMANDE D; CIAPPONI A

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2015

1932-6203

Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi (T. cruzi). It isendemic in Latin American countries outside the Caribbean. The current criterion for cure inthe chronic phase of the disease is the negativization of at least two serological tests suchas enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence assay (IIF)and indirect hemagglutination assay (IHA). The serological evolution of treated subjectswith chronic T. cruzi infection is variable. Treatment failure is indicated by a positive parasitologicaland/or molecular test (persistence of parasitemia).