Controlled Thermoreversible Formation of Supramolecular Hydrogels Based on Poly(vinyl alcohol) and Natural Phenolic Compounds

EUTI, ESTEBAN M.; WOLFEL, ALEXIS; PICCHIO, MATÍAS L.; ROMERO, MARCELO R.; MARTINELLI, MARISA; MINARI, ROQUE J.; IGARZABAL, CECILIA I. ALVAREZ

MACROMOLECULAR RAPID COMMUNICATIONS

WILEY-V C H VERLAG GMBH

Año: 2019 vol. 40

1022-1336

Supramolecular hydrogels have promising applications in a wide variety of fields including 3D bioprinting, sensors and actuators, biomedicine, and controlled drug delivery. This communication reports the facile reversible thermotriggered formation of novel pH-responsive supramolecular hydrogels based on poly(vinyl alcohol) (PVA) bonded via dynamic H-bridge with small phenolic biomolecules. PVA and phenolic compounds form a clear solution when they are physically mixed in water at high temperature, but a fast gelation is produced at room temperature through multiple strong H-bonding interactions. The structure and type of functional groups of different phenolic molecules allow preparing hydrogels with tailor-made viscoelastic properties, controlled low phase transition temperature, and pH-dependent swelling behavior. This combination makes these supramolecular networks very interesting candidates to be used in 3D bioprinting and topical drug delivery of thermolabile biomolecules.