Expression of UGA4 gene encoding the ƒÔ-aminolevulinic and ƒ×-aminobutiric acids permease in Saccharomyces Cerevisiae is controlled by amino acid-sensing systems

MARIANA BERMÚDEZ MORETTI; MERCEDES PERULLINI; ALCIRA BATTLE; SUSANA CORREA GARCÍA

ARCHIVES OF MICROBIOLOGY

SPRINGER

Año: 2005 vol. 184 p. 137 - 140

0302-8933

In yeasts, several sensing systems localized to the plasma membrane which transduce information regarding the availability and quality of nitrogen and carbon sources and work in parallel with the intracellular nutrient-sensing systems, regulate the expression and activity of proteins involved in nutrient uptake and utilization. The aim of this work was to establish whether the cellular signals triggered by amino acids modify the expression of the UGA4 gene which encodes theUGA4 gene which encodes the d-aminolevulinic (ALA) and c-aminobutyric (GABA) acids permease. In the present paper, we demonstrate that extracellular amino acids regulate UGA4 expression and that this effect seems to be mediated by the amino acid sensor complex SPS (SSY1, PTR3, SSY5).-aminolevulinic (ALA) and c-aminobutyric (GABA) acids permease. In the present paper, we demonstrate that extracellular amino acids regulate UGA4 expression and that this effect seems to be mediated by the amino acid sensor complex SPS (SSY1, PTR3, SSY5).UGA4 expression and that this effect seems to be mediated by the amino acid sensor complex SPS (SSY1, PTR3, SSY5).SSY1, PTR3, SSY5).