Indicators of Respiratory Syncytial Virus disease severity

RAJAN D; KEEFE EO; MC CRACKEN C; TRAVERS C; GUN H; GEOGHEGAN S; CABALLERO M; ACOSTA PL; POLACK FP; ANDERSON LJ

Bariloche

Simposio; 10th international RSV symposium; 2016

Respiratory syncytial virus (RSV) is the single most important cause of lower respiratory tract infections (LRTIs) in infants and children worldwide. Various biomarkers have been associated with severity of disease but not comprehensively and simultaneously in the same study. In hte present study, to develop disease severity index, we tested several biomarkers that have been previously associated with RSV severity in previously collected and stored RSV positive nasal wash specimens from 63 children with mild, 212 with moderate, 117 with severe disease and 118 RSV negative control group using multiplex luminex plataform and Enzime immuno assay. Our preliminary results show a link between certain cytokine/chemokine expression including IL-10 and MIP-1a and disease severity. A validated index based on these or others biomarkers combined with clinical measures of disease severity likely can help determine effectiveness of RSV vaccines.