Alterations in pulmonary function during Trichinella spiralis infection

FALDUTO GH; ACOSTA PL; VILA C; POLACK FP; VENTURIELLO SM

Mar del Plata

Congreso; Congreso de la Sociedad Argentina de Investigación Clínica; 2016

Sociedad Argentina de Investigación Clínica

Experimental parasitic infection caused by Trichinella spiralis provokes, in the murine model, an early allergic inflammatory response in the lung, before and during the migratory stage (MS) passage through this organ1-2. The present study aimed to analyze whether this allergic response provokes changes in pulmonary function and related parameters at days 1, 2, 3, 6, 9, 13 and 30 post-infection (p.i.).Results: Inflammatory response triggered by T. spiralis alters pulmonary function causing bronchial hyperresponsiveness due to narrowing of airways. Parasite migration, the presence of mast cells and specific IgE cause cell degranulation and increased levels of histamine in BAL. These results contribute to the understanding of lung signs and symptoms observed in human trichinellosis.