INVESTIGADORES
CARACCIOLO Pablo Christian
artículos
Título:
Optimization of poly(L-lactic acid)/segmented polyurethane electrospinning process for the production of bilayered small-diameter nanofibrous tubular structures
Autor/es:
F. MONTINI BALLARÍN; P.C. CARACCIOLO; E. BLOTTA; V. BALLARIN; G.A. ABRAHAM
Revista:
MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 42 p. 489 - 499
ISSN:
0928-4931
Resumen:
The present study is focused on the electrospinning process as a versatile technique to obtain nanofibrous tubular
structures for potential applications in vascular tissue engineering. A bilayered scaffolding structure composed of
poly(L-lactic acid) (PLLA)/bioresorbable segmented polyurethane (SPEU) blends for small-diameter (5mm) vascular
bypass grafts was obtained by multilayering electrospinning. Polymer blend ratios were chosen to mimic
the media and adventitia layers. The influence of the different electrospinning parameters into the fiber formation,
fiber morphology and fiber mean diameter for PLLA, SPEU and two PLLA/SPEU blends were studied. Flat
and two-parallel plate collectors were used to analyze the effect of the electrostatic field on the PLLA nanofiber
alignment in the rotating mandrel.Membrane topography resulted in random or aligned nanofibrous structures
depending on the auxiliary collector setup used. Finally, composition, surface hydrophilicity, thermal properties
and morphology of nanofibrous scaffolds were characterized and discussed. Since the development of tissue
engineered microvascular prostheses is still a challenge, the prepared scaffolding tubular structures are promising
candidates for vascular tissue engineering.