INVESTIGADORES
DE NICOLA Alejandro Federico
artículos
Título:
Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
Autor/es:
JURE, IGNACIO; DE NICOLA, ALEJANDROF; LABOMBARDA, FLORENCIA
Revista:
NEURAL REGENERATION RESEARCH
Editorial:
SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
Referencias:
Lugar: Pasadena; Año: 2019 vol. 14 p. 2029 - 2034
ISSN:
1673-5374
Resumen:
A newrole has emerged for progesterone after discovering its potent actions awayfrom reproduction in both the central and the peripheral nervous system. Theaim of the present report is to discuss progesterone?s mechanisms of actioninvolved in myelination, remyelination and neuroinflammation. The pivotal roleof the classic progesterone receptor is described and evidence is compiledabout progesterone?s direct effects on oligodendrocyte linage and its indirecteffects on oligodendrocyte precursor cell differentiation by decreasing theneuroinflammatory environment.
