A disynaptic feedback network activated by experience promotes the integration of new granule cells

SUNG M. YANG; KARINA A. BÜTTNER; *THESE AUTHORS CONTRIBUTED EQUALLY TO THIS WORK.; SUNG M. YANG; KARINA A. BÜTTNER; *THESE AUTHORS CONTRIBUTED EQUALLY TO THIS WORK.; DAMIANA GIACOMINI *; SILVIO G. TEMPRANA; ALEJANDRO F. SCHINDER; DAMIANA GIACOMINI *; SILVIO G. TEMPRANA; DIEGO D. ALVAREZ *; ALEJANDRO F. SCHINDER; MARIELA F. TRINCHERO; NATALIA BELTRAMONE; DIEGO D. ALVAREZ *; MARIELA F. TRINCHERO; NATALIA BELTRAMONE

SCIENCE

AMER ASSOC ADVANCEMENT SCIENCE

Año: 2016 vol. 354 p. 459 - 465

0036-8075

*These authors contributed equally to this work.Experience shapes the development and connectivity of adult-born granule cells (GCs) through mechanisms that are poorly understood. We examined the remodeling of dentate gyrus microcircuits in mice in an enriched environment (EE). Short exposure to EE during early development of new GCs accelerated their functional integration. This effect was mimicked by in vivo chemogenetic activation of a limited population of mature GCs. Slice recordings showed that mature GCs recruit parvalbumin γ-aminobutyric acid?releasing interneurons (PV-INs) that feed back onto developing GCs. Accordingly, chemogenetic stimulation of PV-INs or direct depolarization of developing GCs accelerated GC integration, whereas inactivation of PV-INs prevented the effects of EE. Our results reveal a mechanism for dynamic remodeling in which experience activates dentate networks that ?prime? young GCs through a disynaptic feedback loop mediated by PV-INs.