A Preliminary Comparison of P-Tool Consistency

SPETALE, FLAVIO; CAILLOUX, OLIVIER; FERNANDEZ-CALERO, TAMARA; BULACIO, PILAR; TAPIA, ELIZABETH; GUILLAUME, SERGE; DESTERCKE, SEBASTIEN; MURILLO, JAVIER; KRSTICEVIC, FLAVIA; VASQUEZ, GUSTAVO; PONCE, SERGIO

CLAIB 2019: : VIII Latin American Conference on Biomedical Engineering and XLII National Conference on Biomedical Engineering

Springer

Lugar: Cham; Año: 2019; p. 731 - 735

Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.