Curcumin inhibits Leydig cell tumor growth: in vitro and in vivo studies.

RAICES, TRINIDAD; BESIO MORENO, MARCOS; PIGNATARO, OMAR PEDRO; VARELA, MARÍA LUISA; MONDILLO, CAROLINA; ABIUSO, ADRIANA MARÍA BELÉN; PEREYRA, ELBA NORA

Mar del Plata

Congreso; LXIV Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2019

SAIC

Leydig cells (LC) comprise the steroidogenic population of the testes. Leydig cell tumors (LCT) are the most common non-germ cell gonadal tumor developing in the testicular interstitium. Symptoms include virilization in prepuberal boys and erectile disfunction, infertility and/or gynecomastia in adults. Herein, we investigated the in vitro and in vivo effect of curcumin, component of the traditional medicinal spice known as turmeric, on MA-10 tumoral LC. Given the vast evidence of this compound?s therapeutic effects in a variety of pathological conditions, we hypothesized that curcumin reduces LCT growth. Cell proliferation, measured in vitro by the sulforhodamine B assay, was concentration-dependently inhibited by curcumin from 40 and 60 µM concentration after incubations of 24 and 48 h, respectively (p