ORAL DAILY MELATONIN SUPLEMENTATIONATTENUATES OXIDATIVE STRESS IN TESTES OF MEN WITH IDIOPATHIC INFERTILITY

ROSSI SP ; LEVALLE O ; CALANDRA RS ; PONZIO R ; RIVIERE E ; MARTÍNEZ G; MATZKING ME ; PUIGDOMENECH E ; TERRADAS C ; FRUNGIERI MB

Mar del Plata

Congreso; Reunión de la Sociedad Argentina de Investigación Clínica; 2019

Sociedad Argentina de Investigación Clínica

ORAL DAILY MELATONIN SUPLEMENTATIONATTENUATES OXIDATIVE STRESS IN TESTES OF MEN WITH IDIOPATHIC INFERTILITYRIVIERE EUGENIA1, ROSSI SOLEDAD PAOLA2,PONZIO ROBERTO3,PUIGDOMENECHELISA4LEVALLE OSCAR5,MARTINEZ GUSTAVO6, TERRADAS CLAUDIO7,CALANDRA RICARDO SAÚL8,MATZKIN MARÍA EUGENIA9,FRUNGIERI MÓNICA BEATRIZ101Instituto de Biología y Medicina Experimental, IBYME-CONICET;Cátedra de Química, Ciclo Básico Común, UBA2Instituto de Biología y Medicina Experimental, IBYME-CONICET; Departamento de Bioquímica Humana, Facultad de Medicina, UBA3Instituto de Investigaciones enReproducción, Facultad de Medicina, UBA4Instituto Médico PREFER5División Endocrinología, Hospital Durand, Facultad de Medicina, UBA6Fertilidad San Isidro, Instituto Médico de Alta Complejidad7Instituto Médico PREFER; División Endocrinología, Hospital Durand, Facultad de Medicina, UBA; Fertilidad San Isidro, Instituto Médico de Alta Complejidad8Instituto de Biología y Medicina Experimental,IBYME-CONICET9Instituto de Biología y Medicina Experimental, IBYME-CONICET; Departamento de Bioquímica Humana, Facultad de Medicina, UBA10Instituto de Biología y Medicina Experimental,IBYME-CONICET; Cátedra de Química, Ciclo Básico Común, UBAAbstract:Melatonin (mel) modulates testicular function acting indirectly through the hypothalamus/pituitaryand directly on differentgonadalcells. We previously demonstrated thattesticular expression of several inflammatory markers was increasedinbiopsies of infertile patients compared to biopsies of men with normal spermatogenesis. Oral mel in take attenuated testicular inflammation in infertile patients.Because inflammation and oxidative stress are co-dependent pathophysiological processes, and mel is known as a potent antioxidant agent,in this study we evaluated the impact of oral mel supplementation on testicular oxidative state in infertile patients.Testicular biopsies of patients with idiopathic infertility (n=35)and normal histology (n=6) were used. Asub-group of infertilepatients (n=11) were under mel supplementation (3 mg single oral daily dose) to treat sleep disorders.Mel concentration was lower in testes of infertile patients compared to gonads of men withnormal morphology. Oral daily mel in take in infertile patients restored testicular mel concentration close to control levels(p