MRP4 is a metastasic enhancer in pancreatic cancer

DE SOUSA SERRO M; SHAYO C; MAY M; DI SIERVI N; SAHORES A; GOMEZ N; DAVIO C

Bariloche

Simposio; The Fourth South American Symposium in Signal Trasduction and Molecular Medicine; 2018

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies, in part due to its propensity for metastasis. There is an urgent need of novel strategies to target PDAC and improve its prognosis. Recent evidence from our lab shows that pancreatic cancer cell lines and tumors express higher levels of MRP4 compared to adjacent tissue. This transporter proved to be critical for PDAC cell proliferation and tumorigenicity. The aim of this study was to evaluate MRP4 role in pancreatic cancer metastasis. We first analyzed MRP4 expression level of PDAC primary tumors, surrounding non-tumoraltissue, hematological and circulatory tumor cells (CTC) from GEO:GSE18670 dataset. Whole genome microarray analysis showed that CTC depict higher MRP4 levels compared to normal (p