“Niveles endógenos hormonales en la esclerosis lateral amiotrófica (ELA)

GARGIULO MONACHELLI, G.M; MEYER M; GARAY L; DE NICOLA A. F.; GONZALEZ DENISELLE MC

Bs As, Argentina

Congreso; Reunion anual de la Sociedad Argentina Biológica (SAB); 2009

Sociedad Argentina Biológica (SAB)

&amp;lt;!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0in; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:8.5in 11.0in; margin:1.0in 1.25in 1.0in 1.25in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} --&amp;gt; &lt;!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0in; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:8.5in 11.0in; margin:1.0in 1.25in 1.0in 1.25in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} --&gt; ENDOGENOUS HORMONAL LEVELS IN AMYOTROPHIC LATERAL SCLEROSIS (ALS). Gargiulo Monachelli G1,2, Meyer M2, Garay L2,3, De Nicola AF2,3, Gonzalez Deniselle MC2,3. 1. Neurology Department. Ramos Mejia Hospital. 2. IBYME-CONICET. 3. Dep. of Biochemistry. UBA ALS is a neurodegenerative disease. Older age, shorter time to diagnosis (TD), bulbar onset and rapid progression are factors of worse prognosis. We determined serum levels of progesterone (PROG), cortisol, total testosterone and oestradiol, and correlated them with prognostic factors and survival. We measured hormones in 27 patients and 21 controls by radioimmunoassay. Hormonal levels: in ALS were 1.09 to 1.4 fold higher than controls: PROG [ALS (mean ±SEM): 0.55±0.06ng/ml vs control: 0.38±0.04 (p<0.05)], cortisol [17.02±1.60mg/dl vs 11.83±1.38 (p<0.05)], testosterone [306.15±55.94pg/ml vs 213.06±45.52 (p=ns)] and oestradiol [12.22±1.72pg/ml vs 11.15±2.50 (p=ns)]. Prognostic factors: PROG showed a negative correlation with age (RRho= -0.48, p=0.01), positive with TD (RRho=0.36, p=0.06), lower levels in bulbar onset patients (p=0.05) and rapid progressors (p=0.008). Survival: positive correlation with PROG (RRho=0.43, p=0.04). No association with prognostic factors was demonstrated among the other hormones. Discussion: increased hormonal levels in ALS can be due to activation of the hypothalamic-pituitary-adrenal axis. Nevertheless, only PROG showed an association with good prognostic factors and survival. We hypothesize endogenous PROG might display a differential role in neuroprotection.