Arsenite in Drinking Water Alters Glucose Tolerance, Insulin Secretion, HOMA-IR and Oxidative Stress in Offspring.

CLARA COCCA; NADIA BOURGUIGNON; VICTORIA A.R. LUX-LANTOS.; CLARA VENTURA; MARIA MARTA BONAVENTURA; CARLOS LIBERTUN; MARIANNE BIZZOZZERO HIRIART

Orlando, FL.

Congreso; The Endocrine Society (USA). 101th Annual Meeting, Orlando, FL.; 2017

The Endocrine Society

The major source of human exposure to inorganic Arsenic is drinking water. We determined the effects of exposure to Arsenic from conception to adulthood on the glucose metabolism and oxidative stress in rats. We administered sodium arsenite in drinking water [0 (C), 5 (A5) or 50 ppm (A50)] to Sprague Dawley rats from gestational day 1 to weaning of their offspring. Offspring continued with the same treatment as their mothers. Glucose tolerance and Insulin secretion test (TTG and IST, 2 g glucose/kg body weight, i.p.), HOMA-IR and signs of oxidative stress in liver were evaluated in offspring at 8 weeks of age.Females but not males, showed glucose intolerance in the GTT (Two-way ANOVA with repeated-measures: females GTT: interaction: ns, main effect treatment: p