Aging-associated inflammation in testes of Syrian hamsters

PAULA VALCHI; MARIA EUGENIA MATZKIN; RICARDOS SAÚL CALANDRA ; MONICA FRUNGIERI

Buenos Aires

Congreso; Reunion conjunta de sociedades de Biociencias; 2018

Aging constitutes a universal, multi-factorial, progressive and irreversible process. Although the aging process may vary among different tissues, it is usually associated to a chronic inflammatory condition. Relevant to male reproductive aging, we have previously shown an inverse association between longevity and testicular pro-inflammatory state in mouse models with delayed (Ames dwarf Prop1-/- and growth hormone releasing hormone‐knockout mice) or accelerated (growth hormone‐transgenic mice) aging. In this study, we analyzed testicular aging in a physiological animal model. To this aim, testes from young adults (5m: 5 months) and aged Syrian hamsters (20m-22m: 20-22 months) were used. Immunohistochemical studies confirmed an aged-related significant increase in total numbers of Iba1-immunoreactive testicular macrophages (MAC) in which interstitial MACs solely accounted for the rise (Total testicular MAC/mm2, 5m: 66.28±6.67a; 20m: 110.00±10.00b; 22m: 120.50±14.50b; Mean+SEM, p