ADMINISTRATION OF NATIVE PLANTS DECOCCTIONS IN NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS

MAGRINI-HUAMA;N, R.N; COIRINI, H.; KRUSE, M.S.; FERESIN, G. E,; REY, M.; TAPIA, A.

CABA

Congreso; Reunion Conjunta de Sociedades de Biociencias; 2017

SAIC-SAIB-SAB-y otras sociedades

Diabetes mellitus is a chronic disease that represents a major problem for thecountries health systems. Thus the search of new alternative treatments isconstant. Numerous studies indicate that 85% of world population still uses?medicinal plants? to treat its health. Oxalis erythrorhiza (Oe) and Tessariaabsinthioides (Ta) are two species that growth in Argentine, in Cuyoregion, and are consumed to regulate the glucose (Glu) and cholesterol (Chol)levels, even when their effects lack of scientific support. On the other hand, theliver X receptors (LXRα and LXRβ) are related with the systemic Cholclearance and the Glu metabolism in the hypothalamus (HT). Forty two days oldmale rats (SD), diabetics (Ed, i.p. STZ 30mg/ Kg) or controls (C, i.p. vehicle)received (5 or 10% W/V) decoctions (Dcs) of Oe (EdOe and COe) or Ta (EdTa andCTa), or water (EdW and CW) as drink for 4 weeks. Glu, Chol and triglycerides(TG) were determined on weekly obtained blood samples by colorimetric kits. LXRsexpression was evaluated by WB in HT. At the end of the treatment, the Glulevel was lower in EdOe and EdTa (both at 10% W/V) compared to DW (36% and 37%respectively; p<0.05), but higher than CW (147% and 305% respectively;p<0.05). No significant effects were observed in Chol and TG in thesegroups. However, Ta 5%W/V significant reduced the LXRα expression in EdTa compared toEdW (64%; p<0.05) but still was higher than CW. On the other hand, in Edgroups, Oe (10%) and Ta (5% and 10%) reduced LXRβ expression compared to W (20%, 11% and 18% respectively; p<0.05),and also the values were higher than CW group. The Dcs did not produce anyeffect on the parameters evaluated into the C group. Thereby, Oe and Ta couldhave regulatory effects on Glu and LXRs expression. Therefore, a more extendedtreatment will be necessary to achive the research objective and to proposethese native plants like new therapeutic tools. (PIP 0243, PIO-SECITI 2250,CICITCA UNSJ, CONICET).