IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of protein kinases in the development of Tamoxifen and Palbociclib resistance in breast cancer
Autor/es:
MARÍA LAURA POLO; DIEGO ENRICO; LUCÍA ALCOBER BOQUET; MARÍA CECILIA PERRONE; MARÍA PAULA MARKS; VIRGINIA NOVARO; MARÍA JIMENA RODRIGUEZ; MARINA RIGGIO; LUCIANO VELLÓN
Lugar:
Buenos Aires
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
SAIC
Resumen:
It is estimated that approximately 70% of breast tumors express hormone receptors for estrogen (ER) and progesterone (PR). Although ER antagonist tamoxifen has been successful for ER+ breast cancer treatment, a significant amount of these tumors eventually develop resistance. In order to study this phenomenon, we generated a tamoxifen-resistant cell line derived from the human breast cancer cell line T47D (T47D-TR), by long-term cell exposure to progressively increasing concentrations of tamoxifen. This resistant cell line showed an increase in basal activation of ER despite reduction in its expression levels (p