Insulin and glucose differ between normal weight dogs, healthy obese dogs and dogs with hyperadrenocorticism

MICELI DD; RICART MC; CASTILLO VA; GÓMEZ NV; CABRERA BLATTER MF

Praga

Congreso; 31st World Veterinary Congress; 2013

Introduction: Glucose intolerance, insulin resistance and hyperinsulinemia are associated to obesity and Cushing's syndrome (CS). The aim of the study was to analyze whether the response to oral tolerance test of glucose shows differences among dogs with CS, obese and with normal weight. Materials and methods: 6 healthy normoweight dogs (controls), 6 obese without concurrent endocrine disease or any other disease and 6 dogs with CS were studied. All dogs were subjected to test of oral glucose tolerance (4g/kg) measuring blood glucose and insulin in the basal (0), 15, 30, 60 and 120 minutes. Also the HOMA-a (insulin resistance) and HOMA-b (β-cell function) index were calculated taking for this parameters the baseline glucose and insulin values. The results were analyzed using the nonparametric ANOVA test followed Dunn?s test of multiplecomparision of medians. Results: blood glucose and insulin concentrations were significantly higher in dogs with CS at times 0 (p <0.05), 15, 30 (p <0.001) and 60 (p <0.05) vs. obese and controls. HOMA-a and HOMA-b were significantly higher (p <0.01) in dogs with CS than obese and controls. Among the obese and controls these values did not show significant differences. Conclusion: The hypercortisolism is a key factor to determine insulin resistance and glucose intolerance. Dogs with CS have greater possibility of rapidly deplete the pancreatic β-cell and develop Diabetes Mellitus.