HIF-1ALPHA REGULATES TUMOR PROGRESSION IN A HUMAN EPITHELIAL OVARIAN CANCER MODEL.

TESONE MARTA; ESPAÑA DE MARCO MARÍA JOSÉ; PÉREZ CECILIA ; IRUSTA GRISELDA

Congreso; V International Congress in Translational Medicine; 2021

Ovarian cancer is the eighth cause of death in women with cancer. The treatment of this disease has been the same for the past decades, and new drugs are needed. Hypoxia is a common characteristic of solid tumors. The main transcriptional factor involved in this process is Hypoxia Inducible Factor 1 alpha (HIF-1α).The present work aimed to study the effect of Acriflavine (ACR, a specific HIF-1α inhibitor) in the SKOV3 model, a human ovarian cancer cell line, both in vivo and in vitro. For the in vitro experiments, we performed cell proliferation and wound healing assays to assess cell proliferation and migration with different ACR concentrations. Cell proliferation was significantly diminished with ACR 1uM as compared with control cells (1 µM ACR: 22,69 % ± 0,66, p