Progesterone-receptor mediated actions for the treatment of central nervous system disorders: an up-date of the known and the challenge of the unknown

M.C. RAGGIO; M. F. CORONEL; S. L. GONZALEZ; F. LABOMBARDA; M.C. RAGGIO; M. F. CORONEL; S. L. GONZALEZ; F. LABOMBARDA

STEROIDS

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2020 vol. 159

0039-128X

Progesterone has been shown to exert a wide range of remarkable protective actions in experimental models of CNS injury or disease. However, the intimate mechanisms involved in each of these beneficial effects are not fully depicted. In this review, we intend to give the readers a thorough revision on what is known about the participation of diverse receptors and signaling pathways in progesterone-mediated neuroprotective, pro-myelinating and anti-inflammatory outcomes, as well as point out to novel regulatory mechanisms that could open new perspectives in steroid-based therapies.