Lupane Triterpenoids and New Derivatives as Antiproliferative Agents Against Prostate Cancer Cells

MARÍA JULIA CASTRO; MARÍA BELÉN FARAONI; MARÍA JULIA CASTRO; MARÍA BELÉN FARAONI; VALERIA PILAR CAREAGA; ANA PAULA MURRAY; VALERIA PILAR CAREAGA; ANA PAULA MURRAY; PAULA SACCA; JUAN CARLOS CALVO; PAULA SACCA; JUAN CARLOS CALVO

ANTICANCER RESEARCH

INT INST ANTICANCER RESEARCH

Año: 2019 vol. 39 p. 3835 - 3945

0250-7005

Background/Aim: This study examined thepotential role of natural triterpenoids lupeol, calenduladioland heliantriol B2, and a set of 19 derivatives, asantiproliferative and antimetastatic agents against prostatecancer cells. Materials and Methods: Natural triterpenoidswere isolated from Chuqiraga erinaceae. Analogs wereobtained by transformations of lupeol and calenduladiol. Theeffects of compounds on PC-3 and LNCaP cells weredetermined using the MTT assay. Compounds with halfmaximalinhibitory concentration