Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)

ESPINOLA, MARIA SALOME BEZERRA; PRAPAS, NIKOS; UNFER, VITTORIO; FACCHINETTI, FABIO; OZAY, ALI CENK; WDOWIAK, ARTUR; DEWAILLY, DIDIER; VAZQUEZ-LEVIN, MÓNICA

TRENDS IN ENDOCRINOLOGY AND METABOLISM

ELSEVIER SCIENCE LONDON

Año: 2020 vol. 31 p. 570 - 579

1043-2760

It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulinsensitizingagents, and MI is of proven utility in polycystic ovary syndrome(PCOS). In addition, MI plays a pivotal role in the physiology of reproduction,and has beneficial effects on the development of oocytes, spermatozoa, andembryos. By contrast, DCI has little effect on spermatozoa, but high concentrationsin the ovary can negatively affect the quality of oocytes and the blastocyst.Overall, the evidence in the literature supports the beneficial effects of MI in bothfemale and male reproduction, warranting clinical use of MI in assistedreproductive treatment (ART).