IBYME 02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
Autor/es:
HÉCTOR R. MORBIDONI; CECILIA DI CAPUA; AGUSTINA I. DE LA IGLESIA; THOMAS R. IOERGER; VIRGINIA FIGUEROA; TANYA PARISH
Revista:
Access Microbiology
Editorial:
Editorial Manager
Referencias:
Lugar: Londres; Año: 2019
Resumen:
Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis . We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.
