Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism

GARCÍA, JORGE D.; MICELI, DIEGO D.; GARCÍA, JORGE D.; MICELI, DIEGO D.; D'ANNA, ELENA; CASTILLO, VICTOR ALEJANDRO; VIDAL, PATRICIA N.; ARIAS, ELBER SOLER; D'ANNA, ELENA; CASTILLO, VICTOR ALEJANDRO; VIDAL, PATRICIA N.; ARIAS, ELBER SOLER

Open Veterinary Journal

Faculty of Veterinary Medicine, University of Tripoli

Año: 2018 vol. 8 p. 86 - 95

2226-4485

Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs andmetabolic pathways, producing severe adverse effects that endanger the animal?s life. Among these effects,hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism(PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit)concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate ofglomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed asignificantly lower NO nit/nit (P