Interleukin-1â regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model.

FONTANA VANINA; SANCHEZ MELISA; CEBRAL ELISA; CALVO JUAN CARLOS

BIOCELL

INST HISTOL EMBRIOL-CONICET

Lugar: Mendoza; Año: 2010 vol. 34 p. 37 - 43

0327-9545

 Implantation is one of the most regulated processes in human reproduction, by endocrine andimmunological systems. Cytokines are involved in embryo-maternal communication and an impaired bal-ance could result in pregnancy loss. Here we investigated the effect of interleukin 1-â on the activity of twoimportant metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling aswell as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secre-tion. We found that IL-1â activates matrix metalloproteinase activity as well as increases leptin secretion. Wepropose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinaseswhich results in an increased cytotrophoblast invasion.