IMPORTANCIA DE LAS CÉLULAS MADRE MESENQUIMALES EN EL DESARROLLO DEL CÁNCER DE MAMA.

FERNÁNDEZ VALLONE VB,; LABOVSKY V, ; MARTINEZ LM, ; CHASSEING NA.

Acta Bioquímica Clínica Latinoamericana.

FEDERACIÓN BIOQUÍMICA DE LA PROVINCIA DE BUENOS AIRES.

Lugar: La Plata; Año: 2011 vol. 45 p. 679 - 682

1851-6114

Abstract Most of advanced breast cancer patients (BCP) develop osteolytic bone metastasis as a result of the imbalance between osteogenesis, osteoclastogenesis and bone resorption processes. We found in bone marrow  (BM) aspirates of untreated BCP (infiltrative ductal breast carcinoma, clinical stage III and IV, without bone and BM metastasis) a decrease of the cloning efficiency of BM-mesenchymal stem cells (MSC), measured as number of colony forming unit-fibroblasts (CFU-F), and a decrease in its osteogenic differentiation capacity compared to healthy volunteers (HV). Moreover, we observed spontaneous osteoclastogenesis (SpOC) in BM and peripheral blood of BCP, meanwhile SpOC was not observed in BM of HV.  Finally, we consider important the evaluation of the osteogenic differentiation of BM-MSC and osteoclastogenic potential of BM-hematopoietic progenitors as well as peripheral blood-monocytes as possible prognostic factors for future bone disorders that may favor the invasion of BC cells into bone.