INVESTIGADORES
MURRAY Ana paula
artículos
Título:
Lupane Triterpenoids and New Derivatives as Antiproliferative Agents Against Prostate Cancer Cells
Autor/es:
MARIA JULIA CASTRO; CAREAGA, VALERIA P.; SACCA, PAULA; FARAONI, MAR√ćA BELEN; ANA PAULA MURRAY; CALVO, JUAN C.
Revista:
ANTICANCER RESEARCH
Editorial:
INT INST ANTICANCER RESEARCH
Referencias:
Año: 2019 vol. 39 p. 3835 - 3845
ISSN:
0250-7005
Resumen:
Background/Aim: This study examined the potential role of natural triterpenoids lupeol, calenduladiol and heliantriol B2, and a set of 19 derivatives, as antiproliferative and antimetastatic agents against prostate cancer cells. Materials and Methods: Natural triterpenoids were isolated from Chuqiraga erinaceae. Analogs were obtained by transformations of lupeol and calenduladiol. The effects of compounds on PC-3 and LNCaP cells were determined using the MTT assay. Compounds with half-maximal inhibitory concentration