Ultradeformable phospholipid vesicles as a drug delivery system: a review

ROMERO, EDER Y MORILLA, MARIA JOSE

Research and Reports in Transdermal Drug Delivery

DOVE MEDICAL PRESS LTD

Año: 2015 vol. 4 p. 55 - 69

2253-1580

Ultradeformable vesicles are highly deformable (elastic/flexible) liposomes capable of penetrate the intact skin across the stratum corneum and reach the viable epidermis. Ultradeformable vesicles have shown to be more effective than ordinary liposomes in delivering different drugs into and across the mammalian skin. Ultradeformable vesicles have been designed aiming to increase the delivery of non-steroidal anti-inflammatory agents towards musculoskeletal-articular disorders such as osteoarthritis, or to treat skin diseases such as atopic dermatitis, or to deliver anti-infective drugs against epithelial infections and to deliver antihypertensive drugs to blood. Although still there is no commercial product based on this technology, the more advanced is in phase III clinical trials