Nitric oxide (NO) is required for the induction of protective immunity against Salmonella enteritidis.

CERQUETTI MC; GIACOMODONATO MN; GOREN N; SORDELLI DO; ROPOLO A; GRASSO D; VACCARO MI

St. Brieuc, France.

Simposio; Salmonella & Salmonellosis 2002; 2002

Agence Francaise de Securité Sanitaire des Aliments

Nitric oxide (NO) is involved in innate and adaptative immunity. In addition to direct microbicidal actions, NO has immunoregulatory effects relevant to the control of infections. It modulates the cytoquine responses of lymphocytes and the regulation of immune cell apoptosis. We investigated the ability of attenuated strains of S. enteritidis with different protective capacities to induce intestinal inducible NO synthase (iNOS) and apoptosis in Peyer´s patches (PP) in mice.