Hydrodehalogenation of organic halides using CuCl2.2H2O-Li-ARENE (Cat.) combination

FRANCISCO ALONSO; YANINA MOGLIE; GABRIEL RADIVOY; CRISTIAN VITALE; MIGUEL YUS

APPLIED CATALYSIS A-GENERAL

Elsevier Science

Lugar: Oxford; Año: 2004 vol. 271 p. 171 - 176

0926-860X

The hydrodehalogenation of alkyl and aryl halides was efficiently performed using a reducing system composed of CuCl2.2H2O, an excess of lithium sand and a catalytic amount (5 mol%) of 4,4´-di-tert-butylbiphenyl (DTBB) as electron carrier, in tetrahydrofuran at room temperature. The reaction of a series of alkyl and aryl fluorides, chlorides, bromides, and iodides with this combination led to the formation of the corresponding products resulting from a halogen/hydrogen exchange. The use of deuterium oxide instead of water in the copper salt allowed the preparation of the corresponding deuterated products.