INVESTIGADORES
MOGLIE Yanina Fernanda
artículos
Título:
A New Mild Deprotecting Method for O-Benzylsulfonyl Phenols and Alcohols Based on DTBB-Catalyed Lithiation
Autor/es:
FRANCISCO ALONSO; YANINA MOGLIE; CRISTIAN VITALE; GABRIEL RADIVOY; MIGUEL YUS
Revista:
SYNTHESIS-STUTTGART
Editorial:
Georg Thieme Verlag Stuttgart
Referencias:
Lugar: Stuttgart; Año: 2005 p. 1971 - 1976
ISSN:
0039-7881
Resumen:
A variety of alcohols and phenols, protected as the corresponding benzylsulfonic esters, were efficiently deprotected by selective reductive cleavage of the sulfur-oxygen bond, using an excess of lithium sand and a catalytic amount (5 mol%) of 4,4´-di-tert-butylbiphenyl (DTBB) as electron carrier, in tetrahydrofuran at 0º C. This deprotection system was also efficient at -50 ºC and was compatible with a wide range of other functional groups.
