Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection

FARIAS AA; KREMER LE; ALLENDE L; DÍAZ MP; PISANO MB; CONTIGIANI MS; RE VE

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

ELSEVIER SCIENCE INC

Lugar: Oxford; Año: 2013 vol. 107 p. 1 - 6

0035-9203

Background: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis Cvirus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART). Methods: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCVcoinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. Results: Seroprevalence of HCV infection in this population was 26% (62/238).We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (,200CD4cells/ml independentlyof viral load either,or.to100000copies/ml),were significantly associated with immunological and virological responses to HAART. Conclusions: These results showfurther evidence that hepatitis C serostatus is associated with a reduced response to HAART.