Amoxicillin-loaded electrospun scaffolds based on polycaprolactone and nano hydroxyapatite for dental applications

G. RIVERO; G. FURTOS; G.A. ABRAHAM

Santa Fé

Simposio; XI Simposio Argentino de Polímeros; 2015

INTEC

Electrospun matrices composed of poly(å-caprolactone) (PCL) and nanohydroxyapatite (nHAp) loaded with amoxicillin (AMX) were designed for applications in the dental field. PCL can be slowly biodegraded without producing a local acidic environment, while nHAp has good biocompatibility, bioactivity, high osteoconductivity, and/or osteoinductivity properties. Moreover, an antimicrobial property is essential to control and/or reduce bacterial contamination of periodontal defects as well as to enhance the regeneration. Fibrous nanocomposites were obtained by varying the concentration of nHAp and antibiotic loading content. Uniform fibers were produced in all cases and structural, morphological, thermal and surface properties were characterized. The antimicrobial activity of the different compositions depends on both the drug and the nHAp content. The incorporation of AMX seems to alter the nHAp distribution within the matrix. Biomineralization in simulated body fluid (SBF) was evidenced by SEM/EDAX. The studied electrospun scaffolds could be a promising biodegradable material for dental applications.