Preliminary study on the optimization of chitosan nanoparticles processing using the electrospraying technique for embelin encapsulation

A. MARTINEZ CEBADA; A.L. SUARES SEGURA; B. LIMA; A. TAPIA; G.A. ABRAHAM; P.R. CORTEZ TORNELLO

Mar del Plata

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials (COLAOB 2023); 2023

INTEMA (UNMdP-CONICET)

The development of polymeric nanoparticles has become the subject of intense research in the field of Health by Bioengineering and Materials Engineering, as it allows the creation of highly functional systems with applications in disease diagnosis, prevention, and treatment. These nanoparticles have found significant use as biomaterials for the release of therapeutic agents. Chitosan is a natural polymer abundant in nature, holds great importance in the biomedical field due to its excellent properties of biodegradability, biocompatibility, mucoadhesion, films-forming capability, hemostatic and absorption-promoting properties. Moreover, it exhibits antimicrobial, anticholesterolemic, and antioxidant activities. The objective of this work is to optimise the processing conditions for obtaining Chitosan nanoparticles using the monoaxial electrospraying technique, as well as to encapsulate of embelin using coaxial electrospraying.