Electrospun mats based on ethylcellulose loaded with functionalized porphyrins for the inactivation of resistant bacteria

D. HEREDIA; E. GONZÁLEZ; A. DURANTINI; S. MARTINEZ ; G.A. ABRAHAM; S. BONGIOVANNI ABEL

Mar del Plata

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials (COLAOB 2023); 2023

INTEMA (UNMdP-CONICET)

The increase in bacterial resistance is a pressing issue that requires immediate attention. Numerous studies have focused on the utilization of nanostructured materials in recent years. However, a significant portion of these studies still rely on antibiotics/drugs that contribute to the development of resistance in microorganisms. The objective of this research is to fabricate electrospun mats based on ethylcellulose (EC) and incorporate two functionalized porphyrins (TPPF20-Zn TPPF20-Pd) for use in photodynamic inactivation (PDI) of Escherichia coli. This approach aims to address the issue of bacterial resistance by employing a different mechanism of action, circumventing the reliance on antibiotics