Polydopamine functionalized electroconductive Gelatin-PEDOT:PSS matrices for bone regeneration

F. GHORBANI; C. ADLER; M. MONAVARI; G.A. ABRAHAM; A.R. BOCCACCINI

Szczecin

Simposio; 1st Baltic Symposium on Polymer and Biomaterials Science ? Baltic Biomat; 2022

Zachodniopomorski Uniwersytet Technologiczny w Szczecinie

There is a growing health issue related to bone loss caused by trauma or disease that needs to be addressed in order to restore damaged tissues to their original form and function. As an emerging approach, tissue engineering (TE) combines engineering technology with biological principles to restore damaged tissues. Combining a natural polymer such as gelatin with electroconductive PEDOT:PSS can mimic the chemistry and piezoelectricity of bone. Nevertheless, gelatin´s high degree of dissolution increases the need for crosslinking using amine and hydroxyl-modifiers, such as (3-glycidyloxypropyl) trimethoxysilane (GPTMS). Ideally, bone scaffolds are expected to possess both osteoconductive and osteoinductive properties. Consequently, a surface functionalization strategy utilizing mussel-inspired polydopamine (PDA) can provide suitable surfaces for the preabsorption of proteins, as well as better cell adhesion, proliferation, and osteogenic differentiation .This study examined the impact of surface modification by PDA on bioactivity and cell compatibility, as well as the osteogenic performance of the silane-modified gelatin-PEDOT:PSS scaffolds.