INVESTIGADORES
GENARO Ana Maria
artículos
Título:
Involvement of Thyroid Hormones in the Alterations of T-Cell Immunity and Tumor Progression Induced by Chronic Stress.
Autor/es:
FRICK LR; RAPANELLI M; BUSSMANN UA; KLECHA AJ; ARCOS ML; GENARO AM; CREMASCHI GA
Revista:
BIOLOGICAL PSYCHIATRY
Editorial:
Elsevier
Referencias:
Año: 2009 vol. 65 p. 935 - 942
ISSN:
0006-3223
Resumen:
Background: Stress alters the neuroendocrine system, immunity, and cancer. Although the classic stress hormones are glucocorticoids and
catecholamines, thyroid hormones have also been related to stress. We recently reported that chronic restraint stress impairs T-cell
mediated immunity and enhances tumor growth in mice.Stress alters the neuroendocrine system, immunity, and cancer. Although the classic stress hormones are glucocorticoids and
catecholamines, thyroid hormones have also been related to stress. We recently reported that chronic restraint stress impairs T-cell
mediated immunity and enhances tumor growth in mice.
Methods: To study the participation of these hormones on the stress-induced alterations of the immune function and lymphoma growth,
mice were subjected to acute or chronic stress, with or without thyroxin supplementation. Hormone levels, immune status, and cancer
progression were evaluated.To study the participation of these hormones on the stress-induced alterations of the immune function and lymphoma growth,
mice were subjected to acute or chronic stress, with or without thyroxin supplementation. Hormone levels, immune status, and cancer
progression were evaluated.
Results: Differential endocrine alterations were observed in response to acute and chronic stress. Although corticosterone and noradrenaline
levels were increased by acute stress, they were restored after prolonged exposure to the stressor. Instead, thyroid hormone levels were
only reduced in chronically stressed animals in comparison with control subjects. Correlating, chronic but not acute stress impaired T-cell
reactivity. Thyroxin replacement treatment of chronic restraint stress-exposed mice, which restored the euthyroid status, reversed the
observed reduction of T-cell lymphoproliferative responses. Moreover, therapeutic thyroid replacement also reversed the alterations of
lymphoma growth induced by chronic stress in syngeneic mice bearing tumors as well as Interleukin-2 production and specific cytotoxic
response against tumor cells. Finally, we found that the isoforms and of the protein kinase C are involved in these events.Differential endocrine alterations were observed in response to acute and chronic stress. Although corticosterone and noradrenaline
levels were increased by acute stress, they were restored after prolonged exposure to the stressor. Instead, thyroid hormone levels were
only reduced in chronically stressed animals in comparison with control subjects. Correlating, chronic but not acute stress impaired T-cell
reactivity. Thyroxin replacement treatment of chronic restraint stress-exposed mice, which restored the euthyroid status, reversed the
observed reduction of T-cell lymphoproliferative responses. Moreover, therapeutic thyroid replacement also reversed the alterations of
lymphoma growth induced by chronic stress in syngeneic mice bearing tumors as well as Interleukin-2 production and specific cytotoxic
response against tumor cells. Finally, we found that the isoforms and of the protein kinase C are involved in these events. and of the protein kinase C are involved in these events.
Conclusions: These results show for the first time that thyroid hormones are important neuroendocrine regulators of tumor evolution,
most probably acting through the modulation of T-cell mediated immunity affected by chronic stress.These results show for the first time that thyroid hormones are important neuroendocrine regulators of tumor evolution,
most probably acting through the modulation of T-cell mediated immunity affected by chronic stress.