Human outbreak of St. Louis encephalitis detected in Argentina, 2005.

SPINSANTI, LORENA IVANA; DIAZ, LUIS ADRIÁN; GLATSTEIN, NORA; ARSELÁN, SERGIO; MORALES, MARÍA ALEJANDRA; FARÍAS, ADRIÁN ALEJANDRO; FABBRI, CYNTIA; AGUILAR, JAVIER JOSÉ; RÉ, VIVIANA ELIZABETH; FRÍAS, MARÍA; ALMIRÓN, WALTER RICARDO; HUNSPERGER, ELIZABETH; SIRRIN, MARINA; DA ROSA, AMALIA T.; TESH, ROBERT; ENRÍA, DELIA; CONTIGIANI, MARTA SILVIA

JOURNAL OF CLINICAL VIROLOGY : THE OFFICIAL PUBLICATION OF THE PAN AMERICAN SOCIETY FOR CLINICAL VIROLOGY.

Elsevier Science

Lugar: Amsterdam, Holanda; Año: 2008 vol. 42 p. 27 - 33

1386-6532

BACKGROUND: An outbreak of flavivirus encephalitis occurred in 2005 in Córdoba province, Argentina. OBJECTIVES: To characterize the epidemiologic and clinical features of that outbreak and provide the serologic results that identified St. Louis encephalitis virus (SLEV) as the etiologic agent. STUDY DESIGN: From January to May 2005, patients with symptoms of encephalitis, meningitis, or fever with severe headache were evaluated and an etiologic diagnosis achieved by detection of flavivirus-specific antibody sera and cerebrospinal fluid. RESULTS: The epidemic curve of 47 cases showed an explosive outbreak starting in January 2005 with one peak in mid-February and a second peak in mid-March; the epidemic ended in May. Cases occurred predominantly among persons 60 years and older. Nine deaths were reported. SLEV antibodies, when detected in 47 patients studied, had a pattern characteristic of a primary SLEV infection. CONCLUSIONS: Even though isolated cases of St. Louis encephalitis have been reported in Argentina, this is the first description of a large SLEV encephalitis outbreak in Argentina.