Microwave-assisted three component synthesis and in vitro antifungal evaluation of 6-cyano-6,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones. J Heteroc Chem 43, 299-306, 2006.

JAIRO QUIROGA; CISNEROS, C; BRAULIO INSUASTY; RODRIGO ABONIA; CRUZ, S; NOGUERAS MANUEL; DE LA TORRE, J; SORTINO, MAXIMILIANO; ZACCHINO SUSANA

JOURNAL OF HETEROCYCLIC CHEMISTRY

Año: 2006 vol. 43 p. 299 - 306

0022-152X

The reaction of 6-aminopyrimidin-4-ones 1 with benzaldehydes 2 and â-aminocrotononitrile 3 or benzoylacetonitrile 4 under microwave irradiation in dry media yields the 6-cyano-5,8-dihydropyrido[2,3-d]-pyrimidinones 5a-t. The structure of the synthesized compounds was determined on the basis of nmr measurements, especially by 1H,1H-, 1H,13C COSY, DEPT and NOESY experiments. In contrast with other pyrido-[2,3-d]pyrimidine derivatives, these compounds did not show any antifungal in vitro activity up to 250 µg/mL.